STABLE MYOCARDIAL-SPECIFIC LENTI-S100A1 GENE THERAPY RESULTS IN HEART FAILURE AFTER MYOCARDIAL INFARCTION RESCUE
نویسندگان
چکیده
منابع مشابه
Stable myocardial-specific AAV6-S100A1 gene therapy results in chronic functional heart failure rescue.
BACKGROUND The incidence of heart failure is ever-growing, and it is urgent to develop improved treatments. An attractive approach is gene therapy; however, the clinical barrier has yet to be broken because of several issues, including the lack of an ideal vector supporting safe and long-term myocardial transgene expression. METHODS AND RESULTS Here, we show that the use of a recombinant aden...
متن کاملToward Heart Failure After Myocardial Infarction Cardiac S100A1 Protein Levels Determine Contractile Performance and Propensity
Andrew Remppis, Sven T. Pleger, Brent R. DeGeorge, Jr, Andrea D. Eckhart, Arthur M. Patrick Most, Hanna Seifert, Erhe Gao, Hajime Funakoshi, Mirko Völkers, Jörg Heierhorst, Toward Heart Failure After Myocardial Infarction Cardiac S100A1 Protein Levels Determine Contractile Performance and Propensity Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2006 American Heart Association, Inc. ...
متن کاملCardiac S100A1 protein levels determine contractile performance and propensity toward heart failure after myocardial infarction.
BACKGROUND Diminished cardiac S100A1 protein levels are characteristic of ischemic and dilated human cardiomyopathy. Because S100A1 has recently been identified as a Ca2+-dependent inotropic factor in the heart, this study sought to explore the pathophysiological relevance of S100A1 levels in development and progression of postischemic heart failure (HF). METHODS AND RESULTS S100A1-transgenic...
متن کاملAcute heart failure after myocardial infarction.
We compared two groups of patients after acute myocardial infarction. First group was treated with fibrinolytics and they were hospitalized within six hours from the beginning of the first chest-symptoms, and second group that did not come within optimal time was treated with anticoagulants only. The patients were classified according to Killip-classification, shock-index and TIMI-risk-score af...
متن کاملPrevention of Heart Failure after Myocardial Infarction
Heart failure with preserved ejection fraction (HFpEF) is highly prevalent and is frequently associated with metabolic risk factors. Patients with HFpEF have only a slightly lower mortality than patients with HF and reduced EF. The pathophysiology of HFpEF is currently incompletely understood, which precludes specific therapy. Both HF phenotypes demonstrate distinct cardiac remodeling processes...
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ژورنال
عنوان ژورنال: Heart
سال: 2012
ISSN: 1355-6037,1468-201X
DOI: 10.1136/heartjnl-2012-302920a.171